解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Silk was easily dyed in traditional textile industry because of its strong affinity to many colorants. Herein, the biocompatible silk fibroin was firstly extracted from Bombyx mori silkworm cocoons. And SF nanoparticles (SFNPs) were prepared for dyeing indocyanine green (ICG) and construct a therapeutic nano-platform ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1428244
更新日期:2018-11-01 00:00:00
abstract::Lung cancer is still the most common cancer globally. Early screening remains the key to improve the prognosis of patients. There is currently a lack of specific and sensitive methods for early screening of lung cancer. In recent years, studies have found that microRNA plays an important role in the occurrence and dev...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1516003
更新日期:2018-11-01 00:00:00
abstract::The combination of protein-coated graphene oxide (GO) and microencapsulation technology has moved a step forward in the challenge of improving long-term alginate encapsulated cell survival and sustainable therapeutic protein release, bringing closer its translation from bench to the clinic. Although this new approach ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474966
更新日期:2018-11-01 00:00:00
abstract::A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed. Its targeting efficiency and cytotoxicity against non-small cell lung cancer (NSCLC) highly expressing α7-nAChR was invest...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436097
更新日期:2018-11-01 00:00:00
abstract::At present, the chemotherapy of advanced inoperable liver cancer is limited with serious side effects. Curcumin possesses multiple cancer preventive activities and low safety concerns. However, its poor solubility and instability in water pose significant pharmacological barriers to its clinical application. In this s...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1526227
更新日期:2018-11-01 00:00:00
abstract::Bevacizumab is an anti-vascular endothelial growth factor drug that can be used to treat choroidal neovascularization (CNV). Bevacizumab-loaded multivesicular liposomes (Bev-MVLs) have been designed and developed to increase the intravitreal retention time of bevacizumab and reduce the number of injection times. In th...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1474967
更新日期:2018-11-01 00:00:00
abstract::The aim of the current study was to formulate terconazole (TCZ) loaded polymeric mixed micelles (PMMs) incorporating Cremophor EL as a stabilizer and a penetration enhancer. A 23 full factorial design was performed using Design-Expert® software for the optimization of the PMMs which were formulated using Pluronic P123...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2018.1436098
更新日期:2018-11-01 00:00:00
abstract::To prolong the circulation time of drug, PEGylation has been widely used via the enhanced permeability and retention (EPR) effect, thereby providing new hope for better treatment. However, PEGylation also brings the "PEG dilemma", which is difficult for the cellular absorption of drugs and subsequent endosomal escape....
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.1080/10717544.2017.1388451
更新日期:2017-12-01 00:00:00
abstract::Atorvastatin (AT) is a widely used lipid-regulating drug to reduce cholesterol and triglycerides. Its poor aqueous solubility and hepatic metabolism require development of drug delivery systems able to improve its solubility and bypass hepatic effect. For this purpose, atorvastatin nanostructured lipid carriers (AT-NL...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1337823
更新日期:2017-11-01 00:00:00
abstract::A novel niosomal delivery system was designed and investigated for the targeted delivery of daunorubicin (DNR) against acute myeloid leukemia (AML). Anti-CD123 antibodies conjugated to Mal-PEG2000-DSPE were incorporated into normal niosomes (NS) via a post insertion method to afford antibody-modified niosomes (CD123-N...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1333170
更新日期:2017-11-01 00:00:00
abstract::The purpose of this study was to characterize and evaluate tectorigenin-loaded self-microemulsifying drug delivery system (TG-SMEDDS), a previously studied preparation, and further confirm the improvement of TG in solubility and bioavailability. The appearance of TG-SMEDDS was clear and transparent, with good mobility...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1284946
更新日期:2017-11-01 00:00:00
abstract::Usually the topical delivery of ocular drugs poses a great challenge. Accordingly, the work in this study comprised the use of different hybrids of generally regarded as safe (GRAS) oils and surfactants in order to develop and optimize novel acetazolamide (AZD) entrapped-vesicular systems aiming at improving its ocula...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1233588
更新日期:2017-11-01 00:00:00
abstract::To develop statistically optimized brain targeted Tween 80 coated chitosan nanoparticulate formulation for oral delivery of doxycycline hydrochloride for the treatment of psychosis and to evaluate its protective effect on ketamine induced behavioral, biochemical, neurochemical and histological alterations in mice. 32 ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1377315
更新日期:2017-11-01 00:00:00
abstract::Inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis is a chronic autoimmune disease affecting nearly five million people worldwide. Among all drug delivery system, oral administration is the most preferable route for colon-specific targeting and the treatment of IBD. Herein, an amphiphilic ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245367
更新日期:2017-11-01 00:00:00
abstract::Pulmonary bed can retain microparticles (MP) larger than their capillaries' diameter, hence we offer a promising way for lung passive targeting following intravenous (IV) administration. In this study, enoxaparin (Enox)-albumin microspheres (Enox-Alb MS) were, optimally, developed as lung targeted sustained release MP...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1245368
更新日期:2017-11-01 00:00:00
abstract::Recently, genkwanin (GKA) has been shown to display in vitro antitumor activity against some cancer cells, but its poor solubility restricted the in vivo study and further investigation of its antitumor therapeutic efficacy. In this paper, genkwanin nanosuspensions (GKA-NSps) were successfully prepared using D-alpha t...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1384519
更新日期:2017-11-01 00:00:00
abstract::The aim of this work was to develop a novel and more efficient platform for sublingual drug delivery using mosapride citrate (MSP) as a model drug. The engineering of this delivery system had two stages, the first stage was tuning of MSP physicochemical properties by complexation with pure phosphatidylcholine or phosp...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1334719
更新日期:2017-11-01 00:00:00
abstract::Agomelatine (AGM) is an antidepressant drug with a low absolute bioavailability due to the hepatic first pass metabolism. AGM-loaded solid lipid nanoparticles were formulated in the form of an in situ gel to prolong the intranasal retention time and subsequently to increase the absorbed amount of AGM. The optimized in...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1357148
更新日期:2017-11-01 00:00:00
abstract::Polysaccharide nucleic acid fractions of bacillus Calmette-Guérin, termed BCG-PSN, have traditionally been used as immunomodulators in the treatment of dermatitis and allergic diseases. While the sales of injectable BCG-PSN have shown steady growth in recent years, no reports of using BCG-PSN powder or its immunothera...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1391892
更新日期:2017-11-01 00:00:00
abstract::Electro-phonophoresis (EP) has been used as a drug delivery approach in clinical fields. The objective of the present study is to evaluate the skin permeability of isoniazid and rifampin in guinea pigs by EP to provide reference basis for clinical applications of such transdermal delivery system in the treatment of pa...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1267275
更新日期:2017-11-01 00:00:00
abstract::Melatonin, a pineal gland hormone, exerts oncostatic activity in several types of human cancer, including prostate, the most common neoplasia and the third most frequent cause of male cancer death in the developed world. The growth of androgen-sensitive LNCaP prostate cancer cells in mice is inhibited by 3 mg/kg/week ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1338793
更新日期:2017-11-01 00:00:00
abstract::The present work aimed to apply the liquid antisolvent precipitation (LAP) method for preparing the apigenin nanoparticles and thereby improving the solubility and bioavailability of apigenin. The different experimental parameters on particle size were optimized through central composite design (CCD) using the Design-...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1399302
更新日期:2017-11-01 00:00:00
abstract::In this study, transdermal etodolac-loaded cubosomes were developed in order to relieve patient pain and joints stiffness by providing stable etodolac concentration at the targeting sites through controlled drug delivery via the noninvasive skin route with more sustaining and less frequent dosing. Different ratios and...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2017.1326539
更新日期:2017-11-01 00:00:00
abstract::Subcutaneous liraglutide-loaded multivesicular liposomes (Lrg-MVLs) were developed as a sustained drug-delivery system for treating diabetes and their properties were characterized. The Lrg-MVLs prepared using a two-step water-in-oil-in-water double emulsification process had a spherical appearance with a mean diamete...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1180723
更新日期:2016-11-01 00:00:00
abstract::In the present study, pluronic lecithin based organogels (PLO gels) were formulated as topical carrier for controlled delivery of mefenamic acid. Ten organogel formulations were prepared by a method employing lecithin as lipophilic phase and pluronic F-127 as hydrophilic phase in varying concentrations to study variou...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1212439
更新日期:2016-11-01 00:00:00
abstract::Currently, traumatic brain injury (TBI) is the leading cause of death or disabilities in young individuals worldwide. The multi-complexity of its pathogenesis as well as impermeability of the blood-brain barrier (BBB) makes the drug choice and delivery very challenging. The brain-derived neurotrophic factor (BDNF) reg...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.1080/10717544.2016.1199609
更新日期:2016-11-01 00:00:00
abstract::S-nitrosothiols are a class of NO-donors currently under investigation for the treatment of various diseases. In this study, we developed a novel NO-donor (S-nitrosoglutathione-alginate, SNA) by cross-linking alginate with S-nitrosothiols, which can deliver NO in a sustained manner. This compound can be further evalua...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122676
更新日期:2016-10-01 00:00:00
abstract::Traditional in situ gel forming systems are potential applications for parenteral administration but always accompanied with burst release. To overcome this limitation, the tinidazole (TNZ)-loaded in situ gel forming system using a diblock copolymer, monomethoxy poly(ethylene glycol)-block-poly(d,l-lactide) (mPEG-PDLL...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1061069
更新日期:2016-10-01 00:00:00
abstract::Although meloxicam (MX) is relatively safer than other NSAIDs, adverse effects relating to the gastro-intestinal tract are still a problem when administrated MX at high doses and on the long-term treatment. Drug delivery via skin provides an attractive alternative to oral administration, but is limited by the first la...
journal_title:Drug delivery
pub_type: 杂志文章,评审
doi:10.3109/10717544.2016.1157839
更新日期:2016-10-01 00:00:00
abstract::Improvement of water solubility, dissolution rate, oral bioavailability, and reduction of first pass metabolism of OL (OL), were the aims of this research. Co-amorphization of OL carboxylic acid dispersions at various molar ratios was carried out using rapid solvent evaporation. Characterization of the dispersions was...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2016.1153746
更新日期:2016-10-01 00:00:00
abstract:CONTEXT:Paclitaxel (PTX) and carboplatin (CBP) are widely used for the combined chemotherapy of non-small cell lung cancer (NSCLC). However, the development of multidrug resistance of cancer cells, as well as systemic toxic side effects resulting from nonspecific localization of anticancer drugs to non-tumor areas are ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1035466
更新日期:2016-09-01 00:00:00
abstract::The conjugation of tunable peptides or materials with nanocarriers represents a promising approach for drug delivery to tumor cells. In this study, we report the development of a novel liposomal carrier system that exploits the cell surface binding synergism between photo-sensitive peptides (PSPs) and targeting ligand...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1008707
更新日期:2016-09-01 00:00:00
abstract::Glaucocalyxin A (GLA) is a phytochemical component with multiple pharmacological activities; however, glaucocalyxin A's wider use has been restricted by its poor solubility. In this study, GLA nanosuspensions were prepared with precipitation-combined ultrasonication and were characterized by dynamic light scattering (...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1012311
更新日期:2016-09-01 00:00:00
abstract::In present study, two types of micelles based on sodium cholate (NaC) were prepared through non-covalent bonding interaction and the potential of micelles as oral drug delivery systems for paclitaxel (PTX) was evaluated. Pluronic-chitosan (F127-CS) and Pluronic-poly (acrylic acid) (F127-PAA) copolymers were synthesize...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1028604
更新日期:2016-09-01 00:00:00
abstract:CONTEXT:Intraoral drug delivery as mucosal delivery pathway provides a huge platform in the pharmaceutical field. OBJECTIVE:Combining mucoadhesiveness and controlled release of thio-poly acrylic acid as advanced excipient for buccal drug delivery. MATERIALS AND METHODS:Mediated by carbodiimide, cysteine was covalentl...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1122673
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Insulin is a hormone used in the treatment of diabetes mellitus. Multiple injections of insulin every day may causes pain, allergic reactions at injection site, which lead to low patient compliance. The aim of this work was to develop and evaluate an efficient solid lipid nanoparticle (SLN) carrier for oral d...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1039666
更新日期:2016-07-01 00:00:00
abstract::The aim of this study was to obtain a stable, amorphous solid dispersion (SD) with Soluplus, prepared by hot-melt extrusion (HME) as an effective and stable oral delivery system to improve the physical stability and bioavailability of the poorly water-soluble simvastatin (SIM), a drug with relatively low Tg. The drug ...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2014.960982
更新日期:2016-07-01 00:00:00
abstract::Colon is an ideal absorptive site for oral protein and peptide drug (insulin), and yet it poses multiple barriers against the drug absorption, such as the barriers against the drug diffusion from colon lumen toward the absorptive mucosa and permeation across colon epithelium. In this study, modified nanoparticles (Tat...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1048489
更新日期:2016-07-01 00:00:00
abstract::In order to enhance the interaction between nanocarrier and gastrointestinal epithelial cells, we developed nanoparticles (NPs) modified with targeting ligand FQSIYPpIK (FQS), which specifically interact with integrin αvβ3 receptor expressing on the intestinal epithelium. The targeting NPs were prepared by coating the...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1058433
更新日期:2016-07-01 00:00:00
abstract::This study aimed to evaluate transdermal delivery of vancomycin hydrochloride using the combination of ethosomes as an encapsulating vesicle and iontophoresis. Ethosomes were prepared and evaluated in terms of electrochemical stability. Cathodal iontophoresis of negatively charged ethosomes and anodal iontophoresis of...
journal_title:Drug delivery
pub_type: 杂志文章
doi:10.3109/10717544.2015.1013200
更新日期:2016-06-01 00:00:00